TTD | Drug: D0L3SA

Drug General Information
Drug ID	D0L3SA
Former ID	DIB021014
Drug Name	T2328
Synonyms	T-2328; T 2328
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541081]
Structure		Download 2D MOL
Formula	C26H26FN3O
InChI	InChI=1S/C26H26FN3O/c1-31-25-12-10-20(22-11-9-18(16-28)14-23(22)27)15-21(25)17-30-24-8-5-13-29-26(24)19-6-3-2-4-7-19/h2-4,6-7,9-12,14-15,24,26,29-30H,5,8,13,17H2,1H3/t24-,26-/m0/s1
InChIKey	BJOOHYLOKXAENV-AHWVRZQESA-N
PubChem Compound ID	10158788
PubChem Substance ID	15151953, 22557508, 40142944, 75869507, 178102372, 231852783, 247057316
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Antagonist	[529254]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541081	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5746).
Ref 529254	Pharmacological characterization of T-2328, 2-fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride, as a brain-penetrating antagonist oftachykinin NK1 receptor. J Pharmacol Sci. 2008 Jan;106(1):121-7. Epub 2008 Jan 11.

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Drug Information