Drug General Information
Drug ID	D0L4PY
Former ID	DIB016349
Drug Name	KB-5492
Drug Type	Small molecular drug
Indication	Peptic ulcer [ICD9: 531-534; ICD10:K25-K27]		Discontinued in Phase 2	[544799]
Company	Kanebo KK
Structure		Download 2D MOL 3D MOL
Formula	C27H34N2O10
Canonical SMILES	c1(c(cc(cc1OC)CN1CCN(CC(=O)Oc2ccc(cc2)OC)CC1)OC)OC.C(=O<br />)(/C=C/C(=O)O)O
CAS Number	CAS 129200-10-8
PubChem Compound ID	6439276
Target and Pathway
Target(s)	Sigma(1)-type opioid receptor	Target Info	Antagonist	[526642], [532713], [533921]
WikiPathways	miR-targeted genes in squamous cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
References
Ref 544799	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001141)
Ref 526642	Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6.
Ref 532713	Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
Ref 533921	Sigma receptor-mediated effects of a new antiulcer agent, KB-5492, on experimental gastric mucosal lesions and gastric alkaline secretion in rats. J Pharmacol Exp Ther. 1994 May;269(2):799-805.

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