Drug General Information
Drug ID	D0L5XG
Former ID	DIB015388
Drug Name	PF-4191834
Synonyms	PF-04191834
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Phase 2	[523080]
Company	Pfizer Inc
Structure		Download 2D MOL 3D MOL
Formula	C22H23N3O2S
Canonical SMILES	C1CC(CCO1)(C(=O)N)c1cc(ccc1)Sc1ccc(cc1)c1n(ncc1)C
PubChem Compound ID	24986635
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Inhibitor	[530836]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosis
NetPath Pathway	IL4 Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 523080	ClinicalTrials.gov (NCT01147458) A Study Of The Safety And Efficacy Of PF-04191834 In Patients With Osteoarthritis Of The Knee. U.S. National Institutes of Health.
Ref 530836	Pharmacology of PF-4191834, a novel, selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain. J Pharmacol Exp Ther. 2010 Jul;334(1):294-301.

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