Drug Information

Drug General Information
Drug ID
D0L7RU
Former ID
DNC012266
Drug Name
5,7-Dichloro-4-hydroxy-3-phenyl-1H-quinolin-2-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551249]
Structure
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2D MOL

3D MOL
Formula
C15H9Cl2NO2
Canonical SMILES
C1=CC=C(C=C1)C2=C(C3=C(C=C(C=C3NC2=O)Cl)Cl)O
InChI
1S/C15H9Cl2NO2/c16-9-6-10(17)13-11(7-9)18-15(20)12(14(13)19)8-4-2-1-3-5-8/h1-7H,(H2,18,19,20)
InChIKey
ZIMBGBQTQUNKLP-UHFFFAOYSA-N
PubChem Compound ID
54710618
Target and Pathway
Target(s) Glutamate [NMDA] receptor subunit epsilon 2 Target Info Inhibitor [551249]
Glutamate [NMDA] receptor subunit epsilon 1 Target Info Inhibitor [551249]
NMDA receptor subunit NR1 Target Info Inhibitor [551249]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Dopaminergic synapse
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholism
Systemic lupus erythematosushsa04014:Ras signaling pathway
Calcium signaling pathway
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database ErbB4 signaling events
Reelin signaling pathwayreelinpathway:Reelin signaling pathway
Reactome EPHB-mediated forward signaling
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
RAF/MAP kinase cascade
WikiPathways Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction
Alzheimers DiseaseWP706:SIDS Susceptibility Pathways
Spinal Cord Injury
BDNF signaling pathway
Alzheimers Disease
References
Ref 551249Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993).
Ref 551249Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993).

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