Drug Information

Drug General Information
Drug ID
D0L8DL
Former ID
DNC004073
Drug Name
WIN-63395
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551308]
Structure
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2D MOL

3D MOL
Formula
C19H19N5O4S2
Canonical SMILES
CC(C)C1=CC(=CC2=C1C(=O)N(S2(=O)=O)CSC3=NN=NN3C4=CC=CC=C<br />4)OC
InChI
1S/C19H19N5O4S2/c1-12(2)15-9-14(28-3)10-16-17(15)18(25)23(30(16,26)27)11-29-19-20-21-22-24(19)13-7-5-4-6-8-13/h4-10,12H,11H2,1-3H3
InChIKey
LZCQHGLOTYILCS-UHFFFAOYSA-N
PubChem Compound ID
9889727
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [551308]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 551308A comparative SAR and computer modeling study of benzisothiazolone, mechanism-based inhibitors with porcine pancreatic and human leukocyte elastase, Bioorg. Med. Chem. Lett. 6(24):2941-2946 (1996).
Ref 551308A comparative SAR and computer modeling study of benzisothiazolone, mechanism-based inhibitors with porcine pancreatic and human leukocyte elastase, Bioorg. Med. Chem. Lett. 6(24):2941-2946 (1996).

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