Drug Information

Drug General Information
Drug ID
D0L8QX
Former ID
DNC000740
Drug Name
Homorisedronate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535202]
Structure
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2D MOL

3D MOL
Formula
C8H13NO7P2
Canonical SMILES
C1=CC(=CN=C1)CCC(O)(P(=O)(O)O)P(=O)(O)O
InChI
1S/C8H13NO7P2/c10-8(17(11,12)13,18(14,15)16)4-3-7-2-1-5-9-6-7/h1-2,5-6,10H,3-4H2,(H2,11,12,13)(H2,14,15,16)
InChIKey
ILROXFQHACCDLA-UHFFFAOYSA-N
PubChem Compound ID
128523
PubChem Substance ID
10242070, 14898217, 29307553, 77301312, 103241347, 103995442, 104368319, 126436398, 128186040, 134340088, 135084987, 142915270, 224983787, 234193230, 249516464, 249818648, 249818650
Target and Pathway
Target(s) Farnesyl pyrophosphatesynthetase Target Info Inhibitor [535202]
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
References
Ref 535202Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. J Biol Chem. 2001 Sep 7;276(36):33930-7. Epub 2001 Jul 2.
Ref 535202Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. J Biol Chem. 2001 Sep 7;276(36):33930-7. Epub 2001 Jul 2.

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