Drug Information

Drug General Information
Drug ID
D0L9PY
Former ID
DIB014048
Drug Name
CP-66948
Synonyms
N1-[4-(2-Methyl-1H-imidazol-4-yl)-2-thiazolyl]-N3-pentylguanidine; 4-(2-Methylimidazol-4-yl)-2-(N-pentyldiaminomethyleneamino)thiazole
Drug Type
Small molecular drug
Indication Gastric ulcer [ICD9: 531; ICD10:K25] Discontinued in Phase 1 [544795]
Structure
Download
2D MOL

3D MOL
Formula
C13H20N6S
Canonical SMILES
CCCCCN=C(N)NC1=NC(=CS1)C2=CN=C(N2)C
InChI
1S/C13H20N6S/c1-3-4-5-6-15-12(14)19-13-18-11(8-20-13)10-7-16-9(2)17-10/h7-8H,3-6H2,1-2H3,(H,16,17)(H3,14,15,18,19)
InChIKey
OZSXWXGDJLBJQO-UHFFFAOYSA-N
CAS Number
CAS 101189-47-3
PubChem Compound ID
127772
PubChem Substance ID
14775775, 14873440, 29306975, 80268157, 85213603, 104366590, 126436201, 135083036, 136206919, 233020716
Target and Pathway
Target(s) Histamine H2 receptor Target Info Antagonist [528820], [551871]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 544795Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001137)
Ref 528820CP-66,948: an antisecretory histamine H2-receptor antagonist with mucosal protective properties. Dig Dis Sci. 1991 Dec;36(12):1721-8.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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