Drug General Information
Drug ID	D0L9WN
Former ID	DNC012349
Drug Name	4-(4-Methyl-indan-1-yl)-1H-imidazole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534467]
Structure		Download 2D MOL 3D MOL
Formula	C13H14N2
Canonical SMILES	CC1=CC=CC2=C1CCC2C3=CN=CN3
InChI	1S/C13H14N2/c1-9-3-2-4-11-10(9)5-6-12(11)13-7-14-8-15-13/h2-4,7-8,12H,5-6H2,1H3,(H,14,15)
InChIKey	XXQLSAWUSXSJTK-UHFFFAOYSA-N
PubChem Compound ID	9990325
Target and Pathway
Target(s)	Alpha-1D adrenergic receptor	Target Info	Inhibitor	[534467]
	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[534467]
	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[534467]
	Alpha-1B adrenergic receptor	Target Info	Inhibitor	[534467]
	Alpha-1A adrenergic receptor	Target Info	Inhibitor	[534467]
	Alpha-2C adrenergic receptor	Target Info	Inhibitor	[534467]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretionhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
	Salivary secretionhsa04020:Calcium signaling pathway
	AMPK signaling pathway
NetPath Pathway	IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database	LPA receptor mediated events
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	G alpha (i) signalling events
	G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-390696:Adrenoceptors
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
	Platelet Aggregation (Plug Formation)
	GPCR downstream signalingWP58:Monoamine GPCRs
	Integration of energy metabolism
	Vitamin D Receptor Pathway
	AMPK SignalingWP58:Monoamine GPCRs
	Endothelin Pathways
References
Ref 534467	J Med Chem. 1997 Sep 12;40(19):3014-24.Medetomidine analogs as alpha 2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potential binding interactions with alpha 2-adrenoceptors involving a "methyl pocket".
Ref 534467	J Med Chem. 1997 Sep 12;40(19):3014-24.Medetomidine analogs as alpha 2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potential binding interactions with alpha 2-adrenoceptors involving a "methyl pocket".

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