Drug Information

Drug General Information
Drug ID
D0L9ZQ
Former ID
DIB020291
Drug Name
lysergic acid
Synonyms
D-lysergic acid; isolysergic acid; (+)-lysergic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538865]
Structure
Download
2D MOL
Formula
C16H16N2O2
InChI
InChI=1S/C16H16N2O2/c1-18-8-10(16(19)20)5-12-11-3-2-4-13-15(11)9(7-17-13)6-14(12)18/h2-5,7,10,14,17H,6,8H2,1H3,(H,19,20)/t10-,14-/m1/s1
InChIKey
ZAGRKAFMISFKIO-QMTHXVAHSA-N
PubChem Compound ID
6717
PubChem Substance ID
3134482, 8154352, 14947368, 16265544, 29225666, 46530914, 47437865, 50717561, 57323658, 104312859, 118508167, 126687417, 129873800, 134970930, 134995197, 135650563, 137187447, 142240418, 143552758, 162222468, 162725952, 164761668, 198941263, 223682353, 223745807, 226544011, 241146677
Target and Pathway
Target(s) 5-hydroxytryptamine 5A receptor Target Info Agonist [534080]
5-hydroxytryptamine 1D receptor Target Info Agonist [534292]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 538865(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 139).
Ref 534080Expression of functional mouse 5-HT5A serotonin receptor in the methylotrophic yeast Pichia pastoris: pharmacological characterization and localization. FEBS Lett. 1995 Dec 27;377(3):451-6.
Ref 534292Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. Mol Pharmacol. 1996 Dec;50(6):1567-80.

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