Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0LA1R
|
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| Former ID |
DCL000682
|
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| Drug Name |
AEB07
|
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| Drug Type |
Small molecular drug
|
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| Indication | Transplant rejection [ICD9: 279.5, 996; ICD10:D89.8, T86] | Phase 2 | [536867] | ||
| Company |
Novartis
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C52H71N9O12S2
|
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| Canonical SMILES |
CCC1=C(N=C(C=C1)CCC2CCN(C2=O)CC(=O)NC(CC(=O)O)C3=CN=CC=<br />C3)NC.CC(C)(C(=O)NC(COCC1=CC=CC=C1)C(=O)N2CCC3(CC2)CN(C<br />4=CC=CC=C34)S(=O)(=O)C)N.CS(=O)(=O)O
|
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| InChI |
1S/C27H36N4O5S.C24H31N5O4.CH4O3S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27;1-3-16-6-8-19(27-23(16)25-2)9-7-17-10-12-29(24(17)33)15-21(30)28-20(13-22(31)32)18-5-4-11-26-14-18;1-5(2,3)4/h4-12,22H,13-19,28H2,1-3H3,(H,29,33);4-6,8,11,14,17,20H,3,7,9-10,12-13,15H2,1-2H3,(H,25,27)(H,28,30)(H,31,32);1H3,(H,2,3,4)/t22-;17-,20-;/m10./s1
|
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| InChIKey |
XAOWMNBAVQDQSR-WQDYQDSXSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Protein kinase C | Target Info | Inhibitor | [536867] | |
| References | |||||
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