Drug Information

Drug General Information
Drug ID
D0LC6K
Former ID
DAP001380
Drug Name
Fluticasone
Synonyms
Fluticaps; Fluticaps (TN); Fluticasone (INN); S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate
Drug Type
Small molecular drug
Indication Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] Approved [551871]
Therapeutic Class
Antiinflammatory Agents
Company
Fougera Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL
Formula
C22H27F3O4S
InChI
InChI=1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1
InChIKey
MGNNYOODZCAHBA-GQKYHHCASA-N
CAS Number
CAS 90566-53-3
PubChem Compound ID
5311101
PubChem Substance ID
10017, 7979294, 11056270, 14808289, 14930722, 39340821, 50340646, 92719365, 93166977, 96024676, 103771190, 114155265, 126620874, 126648975, 134357058, 135020359, 136316904, 137100849, 137175471, 141792031, 162179171, 163835393, 175265547, 178103310, 196105622, 226396136
SuperDrug ATC ID
D07AC17; R01AD08; R03BA05
SuperDrug CAS ID
cas=080474142
Target and Pathway
Target(s) Glucocorticoid receptor Target Info Antagonist [535660], [536736]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor network
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Nuclear Receptors Meta-Pathway
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear Receptors
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535660Knockouts model the 100 best-selling drugs--will they model the next 100? Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
Ref 536736Fluticasone furoate nasal spray in allergic rhinitis. Drugs Today (Barc). 2008 Apr;44(4):251-60.

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