Drug Information

Drug General Information
Drug ID
D0LF0O
Former ID
DNC008930
Drug Name
BMS-695735
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Preclinical [548135]
Structure
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2D MOL

3D MOL
Formula
C26H31ClFN7O
Canonical SMILES
CC1=C2C(=CC(=C1)C3CCN(CC3)CCCF)NC(=C4C(=CC=NC4=O)NCCN5C<br />=C(C=N5)Cl)N2
InChI
1S/C26H31ClFN7O/c1-17-13-19(18-4-10-34(11-5-18)9-2-6-28)14-22-24(17)33-25(32-22)23-21(3-7-30-26(23)36)29-8-12-35-16-20(27)15-31-35/h3,7,13-16,18,29,32-33H,2,4-6,8-12H2,1H3/b25-23+
InChIKey
KPIXLYXGTRJJMP-WJTDDFOZSA-N
PubChem Compound ID
16038356
Target and Pathway
Target(s) Insulin-like growth factor I receptor Target Info Inhibitor [529668]
Basic fibroblast growth factor receptor 1 Target Info Inhibitor [529668]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
Endocytosis
PI3K-Akt signaling pathway
AMPK signaling pathway
Focal adhesion
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Long-term depression
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
Glioma
Prostate cancer
Melanomahsa04010:MAPK signaling pathway
Regulation of actin cytoskeleton
Melanoma
Central carbon metabolism in cancer
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascadeP00005:Angiogenesis
FGF signaling pathway
Pathway Interaction Database Plasma membrane estrogen receptor signaling
SHP2 signaling
IGF1 pathway
Posttranslational regulation of adherens junction stability and dissassembly
Integrins in angiogenesis
Stabilization and expansion of the E-cadherin adherens junctionglypican_1pathway:Glypican 1 network
Syndecan-4-mediated signaling events
N-cadherin signaling events
FGF signaling pathway
Reactome IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
WikiPathways Senescence and Autophagy in Cancer
Insulin Signaling
Endochondral Ossification
Focal Adhesion
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Apoptosis
Signaling Pathways in Glioblastoma
TSH signaling pathway
MicroRNAs in cardiomyocyte hypertrophyWP51:Regulation of Actin Cytoskeleton
MAPK Signaling Pathway
Mesodermal Commitment Pathway
Hair Follicle Development: Induction (Part 1 of 3)
Integrated Pancreatic Cancer Pathway
Neural Crest Differentiation
Signaling by FGFR
References
Ref 548135Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022289)
Ref 529668J Med Chem. 2008 Oct 9;51(19):5897-900. Epub 2008 Sep 3.Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activity.

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