Drug Information

Drug General Information
Drug ID
D0LG8E
Former ID
DAP000228
Drug Name
Ephedrine
Synonyms
Acunaso; Afrinol; Besan; Biophedrin; Cenafed; Decofed; Eciphin; Efedrin; Ephedral; Ephedremal; Ephedrin; Ephedrital; Ephedrol; Ephedrosan; Ephedrotal; Ephedsol; Ephendronal; Ephoxamin; Fedrin; Genaphed; Isoephedrine; Kratedyn; Lexofedrin; Manadrin; Mandrin; Maxenal; Myfedrine; Nasol; Neodurasina; PSEUDOEPHEDRINE; Pseudo; Pseudoefedrina; Pseudoephedrine; Pseudoephedrinum; Racephedrine; Robidrine; Sanedrine; Sudafed; Vencipon; Zephrol; Benylin Decongestant; Pedia Care; Sudafed Decongestant; CPDD 0049; Eltor 120; Acunaso (TN); D-Ephedrine; D-Isoephedrine; D-Pseudoephedrine; Efidac/24; Ephedrine (TN); Ephedrine (USP); Ephedrine [USAN:BAN]; Ephedrine l-form; I-Sedrin; L-Ephedrine; L-Pseudoephedrine; Neodurasina (TN); Pseudo 60's; Pseudo-12; Pseudoephedrine (D); Psi-ephedrin; Psi-ephedrine; Trans-Ephedrine; D-psi-Ephedrine; Drixoral N.D.; L(-)-Ephedrine; L(+)-psi-Ephedrine; L-(+)-Ephedrine; L-(-)-Ephedrine; (+)-Ephedrin; (+)-Ephedrine; (+)-Pseudoephedrine; (+)-psi-Ephedrine; (+)-threo-Ephedrine; (+-)-Ephedrine; (-)-Ephedrine; (-)-Pseudoephedrine; (-)-psi-Ephedrine; (-)-threo-Ephedrine; (1R,2R)-Ephedrine; (1S,2R)-Ephedrine; (L)-EPHEDRINE; 1-EPHEDRINE; 1-Sedrin; 649031_ALDRICH
Drug Type
Small molecular drug
Indication Asthma; Bronchitis [ICD9: 466, 490, 491, 493; ICD10:J20-J21, J42, J45] Approved [536322], [540937]
Therapeutic Class
Central Nervous System Stimulants
Company
Ben Venue Laboratories Inc
Structure
Download
2D MOL

3D MOL
Formula
C10H15NO
InChI
InChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10-/m0/s1
InChIKey
KWGRBVOPPLSCSI-WPRPVWTQSA-N
CAS Number
CAS 299-42-3
PubChem Compound ID
9294
PubChem Substance ID
4732, 598368, 7847192, 7979173, 8143173, 8156646, 10517637, 15147083, 15219436, 24848190, 24868714, 29227903, 46507538, 47291377, 47365458, 47736757, 48415944, 48424318, 49965013, 50111064, 57325562, 57392731, 79710055, 99222720, 103492152, 104320122, 117475916, 119525662, 124749764, 124892369, 128443809, 131309442, 134975118, 135650234, 136903786, 137001226, 142245143, 160964651, 163418533, 163850169, 175265573, 179150516, 198946050, 223520862, 223667135, 223671453, 223671797, 223786876, 226396713, 241058217
ChEBI ID
ChEBI:15407
SuperDrug ATC ID
C01CA26; R01AA03; R01AB05; R03CA02; S01FB02
SuperDrug CAS ID
cas=000299423
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Agonist [536322]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 536322The effect of alpha-2 adrenergic agonists on memory and cognitive flexibility. Cogn Behav Neurol. 2006 Dec;19(4):204-7.
Ref 540937(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 556).
Ref 536322The effect of alpha-2 adrenergic agonists on memory and cognitive flexibility. Cogn Behav Neurol. 2006 Dec;19(4):204-7.

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