Drug General Information
Drug ID	D0LI3J
Former ID	DNC012203
Drug Name	2-BFi
Synonyms	2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[525733]
Structure		Download 2D MOL 3D MOL
Formula	C11H10N2O
PubChem Compound ID	3080926
Target and Pathway
Target(s)	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[525733]
	Amine oxidase [flavin-containing] B	Target Info	Inhibitor	[529853]
	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[525733]
	Amine oxidase [flavin-containing] A	Target Info	Inhibitor	[525733]
	Alpha-2C adrenergic receptor	Target Info	Inhibitor	[525733]
BioCyc Pathway	Superpathway of tryptophan utilization
	Tryptophan degradation via tryptamine
	Dopamine degradation
	Putrescine degradation III
	Noradrenaline and adrenaline degradationPWY66-401:Superpathway of tryptophan utilization
	Noradrenaline and adrenaline degradation
	Serotonin degradation
	Superpathway of melatonin degradation
	Melatonin degradation II
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa00260:Glycine, serine and threonine metabolism
	Arginine and proline metabolism
	Histidine metabolism
	Tyrosine metabolism
	Phenylalanine metabolism
	Tryptophan metabolism
	Drug metabolism - cytochrome P450
	Metabolic pathways
	Serotonergic synapse
	Dopaminergic synapse
	Cocaine addiction
	Amphetamine addiction
	Alcoholismhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
NetPath Pathway	IL4 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
	5-Hydroxytryptamine degredation
	Dopamine receptor mediated signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00001:Adrenaline and noradrenaline biosynthesis
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database	Alpha-synuclein signaling
PathWhiz Pathway	Histidine Metabolism
	Tyrosine Metabolism
	Glycine and Serine Metabolism
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-390696:Adrenoceptors
	G alpha (z) signalling eventsR-HSA-181430:Norepinephrine Neurotransmitter Release CycleR-HSA-390696:Adrenoceptors
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signalingWP465:Tryptophan metabolism
	Dopamine metabolism
	Phase 1 - Functionalization of compoundsWP58:Monoamine GPCRs
	GPCR downstream signalingWP706:SIDS Susceptibility Pathways
	Biogenic Amine Synthesis
	Oxidative Stress
	Phase 1 - Functionalization of compounds
	Neurotransmitter Release Cycle
	Neurotransmitter Clearance In The Synaptic Cleft
	Serotonin Transporter ActivityWP58:Monoamine GPCRs
	GPCR downstream signaling
References
Ref 525733	Bioorg Med Chem Lett. 2000 Mar 20;10(6):605-7.Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand.
Ref 525733	Bioorg Med Chem Lett. 2000 Mar 20;10(6):605-7.Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand.
Ref 529853	Bioorg Med Chem Lett. 2009 Jan 15;19(2):546-9. Epub 2008 Mar 6.Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors.

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