Drug General Information
Drug ID
D0LL1F
Former ID
DNC011264
Drug Name
[2-Phenylacetophenone]thiosemicarbazone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531200]
Structure
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2D MOL

3D MOL

Formula
C15H15N3S
Canonical SMILES
C1=CC=C(C=C1)CC(=NNC(=S)N)C2=CC=CC=C2
InChI
1S/C15H15N3S/c16-15(19)18-17-14(13-9-5-2-6-10-13)11-12-7-3-1-4-8-12/h1-10H,11H2,(H3,16,18,19)/b17-14+
InChIKey
WHRFFXUXTGIZOH-SAPNQHFASA-N
PubChem Compound ID
Target and Pathway
Target(s) Cathepsin L Target Info Inhibitor [531200]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritis
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 531200Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5. Epub 2010 Sep 15.Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L.
Ref 531200Bioorg Med Chem Lett. 2010 Nov 15;20(22):6610-5. Epub 2010 Sep 15.Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L.

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