Drug General Information
Drug ID	D0LU4S
Former ID	DNC010063
Drug Name	7-butoxy-2H-chromen-2-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530514]
Structure		Download 2D MOL 3D MOL
Formula	C13H14O3
Canonical SMILES	CCCCOC1=CC2=C(C=C1)C=CC(=O)O2
InChI	1S/C13H14O3/c1-2-3-8-15-11-6-4-10-5-7-13(14)16-12(10)9-11/h4-7,9H,2-3,8H2,1H3
InChIKey	BDOGTORASJEUBW-UHFFFAOYSA-N
PubChem Compound ID	156219
Target and Pathway
Target(s)	Carbonic anhydrase XIV	Target Info	Inhibitor	[530514]
	Carbonic anhydrase IX	Target Info	Inhibitor	[530514]
	Carbonic anhydrase VI	Target Info	Inhibitor	[530514]
	Carbonic anhydrase XII	Target Info	Inhibitor	[530514]
	Carbonic anhydrase	Target Info	Inhibitor	[530514]
KEGG Pathway	Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database	HIF-1-alpha transcription factor network
Reactome	Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
	Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide
WikiPathways	Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway
	Reversible Hydration of Carbon Dioxide
	Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon Dioxide
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBase
References
Ref 530514	J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 530514	J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.

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