Drug Information

Drug General Information
Drug ID
D0M0AM
Former ID
DAP001116
Drug Name
Glycopyrrolate
Synonyms
Asecryl; Copyrrolate; Cuvposa; Gastrodyn; Glycopyrronium; Nodapton; Robanul; Robinal; Robinul; Tarodyl; Tarodyn; Bromure de glycopyrronium; Bromure de ritropirronio; Bromure de ritropirronium; Bromuro de glicopirronio; Glycopyrrolate [USAN]; Glycopyrrolate bromide; Glycopyrroni bromidum; Glycopyrronii bromidum; Glycopyrronium bromide; ROBINUL FORTE; Ritropirronium bromide; Ritropirronium bromide [INN]; AHR 504; NVA 237; AD-237; AHR-504; Bromure de glycopyrronium [INN-French]; Bromuro de glicopirronio [INN-Spanish]; Glycopyrrolate (USP); Glycopyrronii bromidum [INN-Latin]; NVA-237; PT-001; Robinul (TN); Salt*); Glycopyrronium bromide (JAN/INN); Beta-1-Methyl-3-pyrrolidyl-alpha-cyclopentylmandelate methobromide; Pyrrolidinium, 3-[(cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethyl-, bromide; Pyrrolidinium, 1,1-dimethyl-3-hydroxy-, bromide, alpha-cyclopentylmandelate; Pyrrolidinium, 3-((cyclopentylhydroxyphenylacetyl)oxy)-1,1-dimethyl-, bromide; Pyrrolidinium, 3-hydroxy-1,1-dimethyl-, bromide, alpha-cyclopentylmandelate; Mandelic acid, .alpha.-cyclopentyl-, ester with 3-hydroxy-1,1-dimethylpyrrolidinium bromide; Pyrrolidinium, 3-hydroxy-1,1-dimethyl-, bromide, alpha-cyclopentylmandelate (8CI); Pyrrolidinium, 3-hydroxy-1,1-dimethyl-, bromide, .alpha.-cyclopentylmandelate; (1,1-dimethylpyrrolidin-1-ium-3-yl)2-cyclopentyl-2-hydroxy-2-phenylacetate; (1,1-dimethylpyrrolidin-1-ium-3-yl) 2-cyclopentyl-2-hydroxy-2-phenylacetate bromide; 1,1-Dimethyl-3-hydroxypyrrolidinium bromide .alpha.-cyclopentylmandelate;1,1-Dimethyl-3-hydroxypyrrolidinium bromide alpha-cyclopentylmandelate; 1-Methyl-3-pyrrolidinyl .alpha.-phenylcyclopentaneglycolate methobromide; 1-Methyl-3-pyrrolidyl alpha-phenylcyclopentaneglycolate methobromide; 3-(erythro-2-Cyclopentyl-2-hydroxy-2-phenylacetoxy)-1,1-dimethylpyrrolidiniumbromid; 3-Hydroxy-1,1-dimethylpyrrolidinium bromide .alpha.-cyclopentylmandelate; 3-Hydroxy-1,1-dimethylpyrrolidinium bromide alpha-cyclopentylmandelate; 3-Hydroxy-1,1-dimethylpyrrolidinium bromide-.alpha.-cyclopentylmandelate
Drug Type
Small molecular drug
Indication Anesthesia [ICD9: 338; ICD10:R20.0] Approved [538189], [542483]
Therapeutic Class
Anticholinergic Agents
Structure
Download
2D MOL

3D MOL
Formula
C19H28NO3+
InChI
InChI=1S/C19H28NO3/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3/q+1
InChIKey
ANGKOCUUWGHLCE-UHFFFAOYSA-N
CAS Number
CAS 596-51-0
PubChem Compound ID
3494
PubChem Substance ID
794727, 4582008, 7351415, 8152218, 11466774, 11467894, 11486407, 29222626, 46509133, 47275736, 47720778, 47869842, 48318623, 49699159, 50124171, 57321838, 80767354, 85209742, 103825408, 104234350, 104303677, 117554810, 124893611, 125081928, 127431325, 136023846, 137008742, 141652405, 141652414, 162108778, 162459186, 163366469, 163368548, 179150741, 184685744, 187051762, 224504317, 226501389, 246480751, 247320628
SuperDrug ATC ID
A03AB02; R03BB06
SuperDrug CAS ID
cas=000596510
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M1 Target Info Antagonist [535754], [536471]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 538189FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040568.
Ref 542483(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7459).
Ref 535754A pharmacological profile of glycopyrrolate: interactions at the muscarinic acetylcholine receptor. Gen Pharmacol. 1992 Nov;23(6):1165-70.
Ref 536471Autonomic cardiovascular control during a novel pharmacologic alternative to ganglionic blockade. Clin Pharmacol Ther. 2008 May;83(5):692-701. Epub 2007 Aug 8.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.