Drug Information

Drug General Information
Drug ID
D0M0VN
Former ID
DIB007545
Drug Name
BISNAFIDE MESILATE
Synonyms
DMP-840; Bisnafide mesilate < Prop INNM >; Bisnafide mesylate < USAN >; (R,R)-2,2'-(Ethane-1,2-diyl)bis[imino(1-methylethane-2,1-diyl)]bis(5-nitro-2,3-dihydro-1H-benzo[de]isoquinoline-1,3-dione) dimethanesulfonate; (R,R)-2,2'-(Ethylenediimino)bis(1-methyl-2,1-ethanediyl)bis(5-nitro-2,3-dihydro-1H-benzo[de]isoquinoline-1,3-dione) dimethanesulfonate
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 2 [545609]
Structure
Download
2D MOL

3D MOL
Formula
C34H36N6O14S2
Canonical SMILES
C[C@H](CNCCNC[C@@H](C)N1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]<br />(=O)[O-])N4C(=O)c5cccc6cc(cc(C4=O)c56)[N+](=O)[O-]
InChI
1S/C32H28N6O8/c1-17(35-29(39)23-7-3-5-19-11-21(37(43)44)13-25(27(19)23)31(35)41)15-33-9-10-34-16-18(2)36-30(40)24-8-4-6-20-12-22(38(45)46)14-26(28(20)24)32(36)42/h3-8,11-14,17-18,33-34H,9-10,15-16H2,1-2H3/t17-,18-/m1/s1
InChIKey
PXBZKHOQHTVCSQ-QZTJIDSGSA-N
CAS Number
CAS 144849-63-8
PubChem Compound ID
60916
Target and Pathway
Target(s) Human DNA Target Info Inhibitor [526841]
References
Ref 545609Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003889)
Ref 526841DNA sequence recognition by bispyrazinonaphthalimides antitumor agents. Biochemistry. 2003 Oct 14;42(40):11751-61.

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