Drug Information

Drug General Information
Drug ID
D0M0XC
Former ID
DIB018727
Drug Name
A839977
Synonyms
A-839977; A 839977
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467466]
Structure
Download
2D MOL
Formula
C19H14Cl2N6O
InChI
InChI=1S/C19H14Cl2N6O/c20-14-7-5-8-15(18(14)21)27-19(24-25-26-27)23-12-13-6-1-2-9-16(13)28-17-10-3-4-11-22-17/h1-11H,12H2,(H,23,24,26)
InChIKey
GMVNBKZQJFRFAR-UHFFFAOYSA-N
PubChem Compound ID
53325875
PubChem Substance ID
124974524, 163679697, 174006406, 178100944, 196372082, 210275023, 210280661, 229319796, 241376879, 243985403, 249618118, 252157893, 252450261, 252477456, 252543494
Target and Pathway
Target(s) P2X purinoceptor 7 Target Info Antagonist [530161]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome The NLRP3 inflammasome
WikiPathways Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
References
Ref 467466(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4122).
Ref 530161The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1alphabeta knockout mice. Behav Brain Res. 2009 Dec 1;204(1):77-81.

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