Drug Information

Drug General Information
Drug ID
D0M1WN
Former ID
DNC012602
Drug Name
L-701324
Drug Type
Small molecular drug
Indication Cerebrovascular ischaemia [ICD9: 434.91; ICD10:I61-I63] Terminated [467575], [525504], [534277]
Structure
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2D MOL

3D MOL
Formula
C21H14ClNO3
InChI
InChI=1S/C21H14ClNO3/c22-14-9-10-17-18(12-14)23-21(25)19(20(17)24)13-5-4-8-16(11-13)26-15-6-2-1-3-7-15/h1-12H,(H2,23,24,25)
InChIKey
FLVRDMUHUXVRET-UHFFFAOYSA-N
PubChem Compound ID
54682505
PubChem Substance ID
6152492, 11113780, 14852666, 24278508, 26751961, 29296662, 46500448, 47734111, 48407477, 50064412, 53859321, 56463203, 57338999, 74478530, 85787790, 91704667, 103202537, 103856997, 103945611, 104397616, 109614211, 124800704, 126433212, 127865846, 134222721, 134349807, 135073053, 135698326, 142472699, 162022759, 162226782, 163772369, 164777554, 170481123, 178101057, 178126151, 179466455, 198983432, 228156678, 241181973, 246643161
Target and Pathway
Target(s) Glutamate [NMDA] receptor subunit epsilon 1 Target Info Inhibitor [527994]
Glutamate [NMDA] receptor subunit epsilon 2 Target Info Inhibitor [527994]
NMDA receptor subunit NR1 Target Info Inhibitor [527994]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Dopaminergic synapse
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholism
Systemic lupus erythematosushsa04014:Ras signaling pathway
Huntington's disease
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
Reelin signaling pathway
Reactome Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
RAF/MAP kinase cascade
WikiPathways Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
BDNF signaling pathwayWP706:SIDS Susceptibility Pathways
Spinal Cord Injury
BDNF signaling pathway
Alzheimers Disease
References
Ref 467575(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4240).
Ref 525504L-701,324, a selective antagonist at the glycine site of the NMDA receptor, counteracts haloperidol-induced muscle rigidity in rats. Psychopharmacology (Berl). 1999 Apr;143(3):235-43.
Ref 534277Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-methyl-D-aspartate receptor complex. J Pharmacol Exp Ther. 1996 Nov;279(2):492-501.
Ref 527994J Med Chem. 2006 Feb 9;49(3):864-71.Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor.

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