Drug General Information
Drug ID
D0M3AP
Former ID
DNC010339
Drug Name
Bis(3-Fluorophenyl)-ketone]thiosemicarbazone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530644]
Structure
Download
2D MOL

3D MOL

Formula
C14H11F2N3S
Canonical SMILES
C1=CC(=CC(=C1)F)C(=NNC(=S)N)C2=CC(=CC=C2)F
InChI
1S/C14H11F2N3S/c15-11-5-1-3-9(7-11)13(18-19-14(17)20)10-4-2-6-12(16)8-10/h1-8H,(H3,17,19,20)
InChIKey
OBIMSARJMGBMKZ-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Cathepsin L Target Info Inhibitor [530644]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Proteoglycans in cancer
Rheumatoid arthritis
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
References
Ref 530644Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9. Epub 2010 Jan 6.Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors.
Ref 530644Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9. Epub 2010 Jan 6.Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors.

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