Drug Information

Drug General Information
Drug ID
D0M3PV
Former ID
DNC004117
Drug Name
L-741626
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539119]
Structure
Download
2D MOL

3D MOL
Formula
C20H21ClN2O
InChI
InChI=1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2
InChIKey
LLBLNMUONVVVPG-UHFFFAOYSA-N
PubChem Compound ID
133633
PubChem Substance ID
7448639, 10243417, 11111363, 11113848, 16830225, 17405303, 24278529, 26752021, 29311516, 46500376, 47500597, 47796125, 48095618, 48170513, 48319567, 48395002, 48395003, 50017904, 50104688, 50104689, 53777848, 57309776, 57344600, 77616850, 85209593, 85231104, 85788761, 90341424, 91706398, 92304247, 103133102, 103247487, 103947637, 104380256, 117463128, 121361530, 124749960, 124799409, 124880518, 124880519, 124880520, 124880521, 125541615, 126728225, 128504576, 134341322, 135089330, 135650487, 135698245, 135710054
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Inhibitor [551224]
D(4) dopamine receptor Target Info Inhibitor [551224]
D(2) dopamine receptor Target Info Inhibitor [551224]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04015:Rap1 signaling pathway
cAMP signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
References
Ref 539119(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 177).
Ref 551224Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626. Bioorg Med Chem. 2010 Jul 15;18(14):5291-300. doi: 10.1016/j.bmc.2010.05.052. Epub 2010 May 24.

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