Drug Information

Drug General Information
Drug ID
D0M4HC
Former ID
DIB012626
Drug Name
L-757464
Synonyms
5-Chloro-2-[4-[4-(2-oxo-2,3-dihydrobenzoxazol-3-yl)piperidin-1-yl]butyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
Indication Prostate hyperplasia [ICD10:N40] Terminated [546739]
Company
Merck & Co Inc
Structure
Download
2D MOL

3D MOL
Canonical SMILES
S1(=O)(=O)N(C(=O)c2c1ccc(c2)Cl)CCCCN1CCC(n2c(=O)oc3c2cc<br />cc3)CC1
CAS Number
CAS 173842-04-1
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Antagonist [546740]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK Signaling
References
Ref 546739Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010051)
Ref 546740Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010051)

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