Drug Information

Drug General Information
Drug ID
D0M5OC
Former ID
DAP000583
Drug Name
Trandolapril
Synonyms
Gopten; Mavik; Odric; Odrik; Preran; Trandolaprilum; Udrik; Trandolaprilum [Latin]; RU 44570; RU44570; Mavik (TN); RU-44570; Trandolapril [INN:BAN]; Trandolapril (JAN/INN); (2S,3aR,7aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester; (2S,3aR,7aS)-1-(N-((1S)-1-((Ethyloxy)carbonyl)-3-phenylpropyl)-L-alanyl)octahydro-1H-indole-2-carboxylic Acid; (2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylicacid; 1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydro-1H-indol-2-carboxylic acid
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Approved [536095], [541594]
Therapeutic Class
Antihypertensive Agents
Company
Abbott Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C24H34N2O5
InChI
InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1
InChIKey
VXFJYXUZANRPDJ-WTNASJBWSA-N
CAS Number
CAS 87679-37-6
PubChem Compound ID
5484727
PubChem Substance ID
7847449, 7980822, 12013675, 14807551, 14929957, 17185447, 39472377, 46508300, 48416651, 49983793, 57364037, 78587898, 90340949, 93166962, 93619661, 103558689, 113992926, 118048541, 121361634, 124893803, 126662049, 131328953, 134223023, 134337874, 135060465, 135569875, 135723472, 136043950, 137002500, 139097173, 144205006, 144206703, 151982735, 152035469, 160848877, 160963864, 162176909, 163122933, 163564878, 164813794, 172919751, 175266111, 175612605, 178103069, 179116928, 184545941, 210279756, 210282079, 223702475, 224010570
SuperDrug ATC ID
C09AA10
SuperDrug CAS ID
cas=087679376
Target and Pathway
Target(s) Angiotensin-converting enzyme Target Info Inhibitor [537291]
KEGG Pathway Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 536095New antiarrhythmic agents for atrial fibrillation and atrial flutter. Expert Opin Emerg Drugs. 2005 May;10(2):311-22.
Ref 541594(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6453).
Ref 537291Selective reduction of central pulse pressure under angiotensin blockage in SHR: role of the fibronectin-alpha5beta1 integrin complex. Am J Hypertens. 2009 Jul;22(7):711-7. Epub 2009 May 7.

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