Drug Information

Drug General Information
Drug ID
D0M5ZE
Former ID
DIB020854
Drug Name
RS 100235
Synonyms
RS100235; RS-100235
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539623]
Structure
Download
2D MOL
Formula
C27H35ClN2O5
InChI
InChI=1S/C27H35ClN2O5/c1-32-23-8-6-19(16-24(23)33-2)4-3-11-30-12-9-18(10-13-30)5-7-22(31)20-17-21(28)25(29)27-26(20)34-14-15-35-27/h6,8,16-18H,3-5,7,9-15,29H2,1-2H3
InChIKey
UVOCSZKGWJOKNN-UHFFFAOYSA-N
PubChem Compound ID
5311416
PubChem Substance ID
7980542, 11056489, 14762238, 39341093, 47510144, 48105261, 57359471, 78646465, 85209375, 103261228, 114156034, 135650932, 136351127, 139396648, 238974920, 245818119
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Antagonist [527202]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539623(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 250).
Ref 527202New insights into the human 5-HT4 receptor binding site: exploration of a hydrophobic pocket. Br J Pharmacol. 2004 Oct;143(3):361-70. Epub 2004 Sep 6.

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