Drug General Information
Drug ID	D0M6YW
Former ID	DIB003027
Drug Name	GYKI-12743
Drug Type	Small molecular drug
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Discontinued in Phase 1	[545079]
Company	Gedeon Richter Ltd
Structure		Download 2D MOL 3D MOL
Formula	C16H20ClN3O3
Canonical SMILES	n1(c(=O)cccn1)CCCNCC1Oc2c(OC1)cccc2.Cl
CAS Number	CAS 110714-10-8
PubChem Compound ID	163825
Target and Pathway
Target(s)	Alpha-2C adrenergic receptor	Target Info	Modulator	[528315]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545079	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002059)
Ref 528315	GYKI-12743 a new postsynaptic vascular alpha-adrenoceptor antagonist. Acta Physiol Hung. 1991;77(3-4):257-67.

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