Drug Information

Drug General Information
Drug ID
D0M8EH
Former ID
DNC010957
Drug Name
O-spiroketal glucoside
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530988]
Structure
Download
2D MOL

3D MOL
Formula
C22H25ClO7
Canonical SMILES
CCOC1=CC=C(C=C1)CC2=C(C=C3COC4(C3=C2)C(C(C(C(O4)CO)O)O)<br />O)Cl
InChI
1S/C22H25ClO7/c1-2-28-15-5-3-12(4-6-15)7-13-8-16-14(9-17(13)23)11-29-22(16)21(27)20(26)19(25)18(10-24)30-22/h3-6,8-9,18-21,24-27H,2,7,10-11H2,1H3/t18-,19-,20+,21-,22+/m1/s1
InChIKey
WUEOKKVPVLUFPP-BDHVOXNPSA-N
PubChem Compound ID
45488072
Target and Pathway
Target(s) Sodium/glucose cotransporter 1 Target Info Inhibitor [530988]
mRNA of sodium-glucosetransporter-2 Target Info Inhibitor [530988]
KEGG Pathway Carbohydrate digestion and absorption
Bile secretion
Mineral absorption
PathWhiz Pathway Lactose Degradation
Trehalose Degradation
Reactome Hexose transport
Na+-dependent glucose transporters
Inositol transportersR-HSA-189200:Hexose transport
Inositol transporters
WikiPathways NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Metabolism of carbohydratesWP2884:NRF2 pathway
References
Ref 530988Bioorg Med Chem. 2010 Jun 15;18(12):4422-32. Epub 2010 Apr 29.ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
Ref 530988Bioorg Med Chem. 2010 Jun 15;18(12):4422-32. Epub 2010 Apr 29.ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.