Drug Information

Drug General Information
Drug ID
D0M8FL
Former ID
DNC012481
Drug Name
2,3,4,5-Tetrahydro-benzo[f][1,4]oxazepine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534195]
Structure
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2D MOL

3D MOL
Formula
C9H11NO
Canonical SMILES
C1COC2=CC=CC=C2CN1
InChI
1S/C9H11NO/c1-2-4-9-8(3-1)7-10-5-6-11-9/h1-4,10H,5-7H2
InChIKey
HDVHFHONOKCUHQ-UHFFFAOYSA-N
PubChem Compound ID
21882775
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Inhibitor [534195]
Alpha-2B adrenergic receptor Target Info Inhibitor [534195]
Alpha-2A adrenergic receptor Target Info Inhibitor [534195]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 534195J Med Chem. 1996 Aug 30;39(18):3539-46.Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-methyltransferase.
Ref 534195J Med Chem. 1996 Aug 30;39(18):3539-46.Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-methyltransferase.

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