Drug Information

Drug General Information
Drug ID
D0M8RC
Former ID
DAP000246
Drug Name
Terbutaline
Synonyms
Asthmasian; Brethaire; Brethine; Brican; Bricanyl; Bricar; Bricaril; Bricyn; Terbutalin; Terbutalina; Terbutalino; Terbutalinum; Terbutalina [DCIT]; Terbutaline sulfate; KWD 2019; Asthmasian (TN); Brethaire (TN); Brethine (TN); Bricanyl (TN); KWD-2019; Terbutaline (INN); Terbutaline [INN:BAN]; Terbutalino [INN-Spanish]; Terbutalinum [INN-Latin]; (+-)-5-(2-((1,1-Dimethylethyl)amino)-1-hydroxyethyl)-1,3-benzenediol; (+-)-Terbutaline; 1,3-Benzenediol, 5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-(9CI); 5-(2-((1,1-DIMETHYLETHYL)AMINO)-1-HYDROXYETHYL)-1,3-BENZENEDIOL; 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol; 5-{2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl}benzene-1,3-diol
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Approved [538303], [540968]
Therapeutic Class
Bronchodilator Agents
Company
Ben Venue Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C12H19NO3
InChI
InChI=1S/C12H19NO3/c1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8/h4-6,11,13-16H,7H2,1-3H3
InChIKey
XWTYSIMOBUGWOL-UHFFFAOYSA-N
CAS Number
CAS 23031-25-6
PubChem Compound ID
5403
PubChem Substance ID
9339, 5639780, 7980759, 8153322, 11335253, 11360492, 11363924, 11366486, 11369048, 11371666, 11374677, 11377210, 11461464, 11466419, 11467539, 11485189, 11486258, 11489143, 11490409, 11492685, 11494844, 15220540, 29224455, 46506887, 47290977, 47290978, 47588833, 47662110, 47885254, 47959569, 48110295, 48110296, 48184837, 48184838, 48334319, 48414500, 48416600, 49698890, 49857687, 49879913, 50105280, 53788504, 56312696, 56314116, 56413058, 57322758, 77381785, 85173277, 85209330, 85789216
SuperDrug ATC ID
R03AC03; R03CC03
SuperDrug CAS ID
cas=023031256
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Agonist [537680]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538303FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 075877.
Ref 540968(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 560).
Ref 537680Evaluation of a new oral beta2-adrenoceptor stimulant bronchodilator, terbutaline. Pharmacology. 1975;13(3):201-11.

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