Drug Information

Drug General Information
Drug ID
D0M8VL
Former ID
DIB013300
Drug Name
GW-870086-X
Synonyms
Glucocorticoid agonist (asthma), GlaxoSmithKline; GW-870086-X (inhaled, asthma), GlaxoSmithKline
Indication Asthma [ICD10:J45] Phase 2 [522149], [523364]
Company
GlaxoSmithKline plc
Structure
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2D MOL

3D MOL
Canonical SMILES
CC1(C)C(C)(C)C1C(=O)O[C@@]1(C(=O)OCC#N)[C@]2(C[C@@H]([C<br />@@]3([C@]4(C=CC(=O)C=C4[C@H](C[C@H]3[C@@H]2C[C@H]1C)F)C<br />)F)O)C
Target and Pathway
Target(s) Glucocorticoid receptor Target Info Agonist [532254]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor network
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Nuclear Receptors Meta-Pathway
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear Receptors
References
Ref 522149ClinicalTrials.gov (NCT00549497) A Randomized Study Evaluating Steroid Hormone Levels, Safety And Tolerability Of GW870086X In Healthy Volunteers. U.S. National Institutes of Health.
Ref 523364ClinicalTrials.gov (NCT01299610) A Study to Test the Effect of 2 Different Doses of Topical GW870086X on Atopic Dermatitis Also Including a Postive Control and a Placebo. U.S. National Institutes of Health.
Ref 532254Unique response profile of trabecular meshwork cells to the novel selective glucocorticoid receptor agonist, GW870086X. Invest Ophthalmol Vis Sci. 2013 Mar 1;54(3):2100-7.

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