Drug Information

Drug General Information
Drug ID
D0M9GO
Former ID
DIB021057
Drug Name
tifluadom
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539030]
Structure
Download
2D MOL
Formula
C22H20FN3OS
InChI
InChI=1S/C22H20FN3OS/c1-26-16(13-25-22(27)15-10-11-28-14-15)12-24-21(17-6-2-4-8-19(17)23)18-7-3-5-9-20(18)26/h2-11,14,16H,12-13H2,1H3,(H,25,27)
InChIKey
NPGABYHTDVGGJK-UHFFFAOYSA-N
PubChem Compound ID
115208
PubChem Substance ID
13961, 6613823, 10236683, 12012790, 14756643, 17396862, 29296737, 50065280, 50436139, 57339052, 85229979, 103427748, 103888313, 103980114, 104397850, 128734870, 134223377, 135072262, 135271684, 135651262, 137249415, 162918958, 223441134, 226508946, 252218720, 252447941
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Agonist [534443]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539030(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1667).
Ref 534443Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands. J Pharmacol Exp Ther. 1997 Aug;282(2):676-84.

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