Drug Information

Drug General Information
Drug ID
D0M9TW
Former ID
DNC009391
Drug Name
3-(4-cyanophenyl)quinoxaline-5-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529901]
Structure
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2D MOL

3D MOL
Formula
C16H10N4O
Canonical SMILES
C1=CC(=C2C(=C1)N=CC(=N2)C3=CC=C(C=C3)C#N)C(=O)N
InChI
1S/C16H10N4O/c17-8-10-4-6-11(7-5-10)14-9-19-13-3-1-2-12(16(18)21)15(13)20-14/h1-7,9H,(H2,18,21)
InChIKey
WCZAODKSIJSHQD-UHFFFAOYSA-N
PubChem Compound ID
25218518
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [529901]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 529901J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.
Ref 529901J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.

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