Drug Information

Drug General Information
Drug ID
D0MA8C
Former ID
DIB019928
Drug Name
GR 125,743
Synonyms
GR125743; GR 125743
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541955]
Structure
Download
2D MOL
Formula
C25H28N4O2
InChI
InChI=1S/C25H28N4O2/c1-18-16-20(4-6-22(18)19-8-10-26-11-9-19)25(30)27-21-5-7-24(31-3)23(17-21)29-14-12-28(2)13-15-29/h4-11,16-17H,12-15H2,1-3H3,(H,27,30)
InChIKey
GNOXPYACARZYMW-UHFFFAOYSA-N
PubChem Compound ID
5311130
PubChem Substance ID
7979435, 11056290, 14782253, 39340848, 47285912, 47805582, 52536468, 53788119, 57359368, 85215719, 114155343, 127979616, 135327359, 135650311, 233307319, 242502003
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Antagonist [534412]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 541955(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 69).
Ref 534412Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy. Naunyn Schmiedebergs Arch Pharmacol. 1997 Jun;355(6):682-8.

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