Drug Information

Drug General Information
Drug ID
D0MD2L
Former ID
DAP001516
Drug Name
Rufinamide
Synonyms
Banzel; Inovelon; Xilep; Cgp 33101; Banzel, Rufinamide; CGP-33101; E-2080; RUF-331; SYN-111; Rufinamide (USAN/INN); 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide; 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-Triazole-4-carboxamide; 1-[(2,6-difluorophenyl)methyl]triazole-4-carboxamide
Drug Type
Small molecular drug
Indication Seizures associated with lennox-Gastaut syndrome [ICD10:R56.9] Approved [529941], [542495], [551871]
Epilepsy [ICD10:G40] Approved (orphan drug) [536845], [542495]
Company
Eisai
Structure
Download
2D MOL

3D MOL
Formula
C10H8F2N4O
InChI
InChI=1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17)
InChIKey
POGQSBRIGCQNEG-UHFFFAOYSA-N
CAS Number
CAS 106308-44-5
PubChem Compound ID
129228
PubChem Substance ID
10242268, 12014051, 15121846, 24724595, 29217641, 29308110, 47207436, 50111716, 56320687, 56323499, 57342925, 58107211, 80334982, 90341717, 90342554, 92718980, 93309661, 99437055, 103771489, 104369993, 109693097, 118317931, 121361738, 124757121, 124772079, 124800269, 125163925, 125337281, 126600262, 126621181, 126651848, 126667055, 128944616, 131293789, 134338700, 134340299, 135085479, 135653558, 135698201, 136343339, 137027833, 137255007, 142190226, 143493273, 144205820, 152241718, 162037521, 162184408, 163124160, 163564750
SuperDrug ATC ID
N03AF03
Target and Pathway
Target(s) Sodium channel Target Info Blocker [536498]
KEGG Pathway Dopaminergic synapse
Reactome Interaction between L1 and Ankyrins
References
Ref 5299412008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
Ref 536845Pharmacological management of epilepsy: recent advances and future prospects. Drugs. 2008;68(14):1925-39.
Ref 542495(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7470).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536498Emerging drugs for epilepsy. Expert Opin Emerg Drugs. 2007 Sep;12(3):407-22.

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