Drug Information

Drug General Information
Drug ID
D0ME8Z
Former ID
DNC008106
Drug Name
5-(2-fluorobenzyloxy)quinazoline-2,4-diamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529261]
Structure
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2D MOL

3D MOL
Formula
C15H13FN4O
Canonical SMILES
C1=CC=C(C(=C1)COC2=CC=CC3=C2C(=NC(=N3)N)N)F
InChI
1S/C15H13FN4O/c16-10-5-2-1-4-9(10)8-21-12-7-3-6-11-13(12)14(17)20-15(18)19-11/h1-7H,8H2,(H4,17,18,19,20)
InChIKey
SFJOSBAEWKPKPY-UHFFFAOYSA-N
PubChem Compound ID
24778025
Target and Pathway
Target(s) Dihydrofolate reductase Target Info Inhibitor [529261]
PathWhiz Pathway Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
References
Ref 529261J Med Chem. 2008 Feb 14;51(3):449-69. Epub 2008 Jan 19.Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy.
Ref 529261J Med Chem. 2008 Feb 14;51(3):449-69. Epub 2008 Jan 19.Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy.

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