Drug General Information
Drug ID
D0MH0Z
Former ID
DNC002539
Drug Name
Phosphoaminophosphonic Acid-Adenylate Ester
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551374]
Structure
Download
2D MOL
Formula
C10H17N6O12P3
Canonical SMILES
C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(NP(=O<br />)(O)O)O)O)O
InChI
1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1
InChIKey
PVKSNHVPLWYQGJ-KQYNXXCUSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Ephrin type-B receptor 2 Target Info Inhibitor [551374]
MAP kinase p38 Target Info Inhibitor [551374]
Mitogen-activated protein kinase 10 Target Info Inhibitor [551374]
DNA topoisomerase II Target Info Inhibitor [551374]
Thymidine monophosphate kinase Target Info Inhibitor [551374]
Insulin-like growth factor I receptor Target Info Inhibitor [551374]
DNA topoisomerase II, beta isozyme Target Info Inhibitor [551374]
Pantothenate kinase Target Info Inhibitor [551374]
DNA repair protein RAD51 homolog 1 Target Info Inhibitor [551374]
Lck tyrosine kinase Target Info Inhibitor [551374]
Glycogen synthase kinase-3 beta Target Info Inhibitor [551374]
Ephrin type-A receptor 2 Target Info Inhibitor [551374]
KEGG Pathway Axon guidancehsa04010:MAPK signaling pathway
Rap1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Oocyte meiosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Amyotrophic lateral sclerosis (ALS)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Influenza A
Epstein-Barr virus infection
Proteoglycans in cancerhsa04010:MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
cAMP signaling pathway
Protein processing in endoplasmic reticulum
Wnt signaling pathway
Focal adhesion
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis B
Herpes simplex infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Choline metabolism in cancermtu00240:Pyrimidine metabolism
Metabolic pathwayshsa04014:Ras signaling pathway
HIF-1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
AMPK signaling pathway
Adherens junction
Long-term depression
Ovarian steroidogenesis
Transcriptional misregulation in cancer
Proteoglycans in cancer
Glioma
Prostate cancer
Melanomahsa03440:Homologous recombination
Fanconi anemia pathway
Pancreatic cancerhsa04064:NF-kappa B signaling pathway
Natural killer cell mediated cytotoxicity
HTLV-I infection
Primary immunodeficiencyhsa04012:ErbB signaling pathway
Chemokine signaling pathway
Cell cycle
Hedgehog signaling pathway
Axon guidance
Hippo signaling pathway
B cell receptor signaling pathway
Melanogenesis
Thyroid hormone signaling pathway
Alzheimer's disease
Measles
Endometrial cancer
Basal cell carcinomahsa04014:Ras signaling pathway
NetPath Pathway TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
PANTHER Pathway AngiogenesisP00003:Alzheimer disease-amyloid secretase pathway
B cell activation
EGF receptor signaling pathway
FGF signaling pathway
Interferon-gamma signaling pathway
Oxidative stress response
Parkinson disease
TGF-beta signaling pathway
Ras Pathway
p53 pathway feedback loops 2
p38 MAPK pathwayP00003:Alzheimer disease-amyloid secretase pathway
Apoptosis signaling pathway
FAS signaling pathway
Integrin signalling pathway
CCKR signaling map STP00032:Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascadeP00017:DNA replicationP00049:Parkinson disease
T cell activationP00004:Alzheimer disease-presenilin pathway
Angiogenesis
Cadherin signaling pathway
Hedgehog signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Insulin/IGF pathway-protein kinase B signaling cascade
Interleukin signaling pathway
PDGF signaling pathway
PI3 kinase pathway
Wnt signaling pathway
CCKR signaling map ST
Pathway Interaction Database EPHB forward signaling
EphrinB-EPHB pathway
Syndecan-2-mediated signaling events
Ephrin B reverse signalingrhoa_pathway:RhoA signaling pathway
Signaling mediated by p38-gamma and p38-deltawnt_noncanonical_pathway:Noncanonical Wnt signaling pathway
CD40/CD40L signaling
FAS (CD95) signaling pathway
Glucocorticoid receptor regulatory network
FoxO family signaling
p75(NTR)-mediated signaling
ErbB2/ErbB3 signaling events
PDGFR-beta signaling pathway
Nephrin/Neph1 signaling in the kidney podocyteer_nongenomic_pathway:Plasma membrane estrogen receptor signaling
SHP2 signaling
IGF1 pathway
Posttranslational regulation of adherens junction stability and dissassembly
Integrins in angiogenesis
Stabilization and expansion of the E-cadherin adherens junctionp73pathway:p73 transcription factor network
ATR signaling pathway
BARD1 signaling eventsnfkappabatypicalpathway:Atypical NF-kappaB pathway
Glypican 1 network
TCR signaling in na&#xef
Signaling events mediated by PTP1B
IL12-mediated signaling events
Regulation of p38-alpha and p38-beta
TCR signaling in na&#xef
Thromboxane A2 receptor signaling
IL2-mediated signaling events
CXCR4-mediated signaling events
Class I PI3K signaling events
IL2 signaling events mediated by PI3K
amb2 Integrin signaling
EPHA forward signaling
IL2 signaling events mediated by STAT5
Ephrin B reverse signaling
Alpha-synuclein signalinglysophospholipid_pathway:LPA receptor mediated events
Degradation of beta catenin
Reelin signaling pathway
Presenilin action in Notch and Wnt signaling
Integrin-linked kinase signaling
CDC42 signaling events
LKB1 signaling events
Canonical Wnt signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
C-MYC pathway
Regulation of Androgen receptor activity
BMP receptor signaling
Hedgehog signaling events mediated by Gli proteins
Signaling events mediated by Stem cell factor receptor (c-Kit)
Validated transcriptional targets of deltaNp63 isoforms
Aurora A signaling
Insulin-mediated glucose transport
Class I PI3K signaling events mediated by Akt
p53 pathway
Trk receptor signaling mediated by PI3K and PLC-gammaephrina_ephapathway:EphrinA-EPHA pathway
Arf6 signaling events
Direct p53 effectors
Stabilization and expansion of the E-cadherin adherens junction
EPHA2 forward signaling
Reactome EPH-Ephrin signaling
L1CAM interactions
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cellsR-HSA-168638:NOD1/2 Signaling Pathway
p38MAPK events
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
CDO in myogenesis
DSCAM interactions
VEGFA-VEGFR2 PathwayR-HSA-2559580:Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factorsR-HSA-2428928:IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1RR-HSA-5685938:HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Presynaptic phase of homologous DNA pairing and strand exchange
Meiotic recombinationR-HSA-114604:GPVI-mediated activation cascade
PIP3 activates AKT signaling
Regulation of KIT signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
PD-1 signaling
Interleukin-2 signalingR-HSA-195253:Degradation of beta-catenin by the destruction complex
AKT phosphorylates targets in the cytosol
Regulation of HSF1-mediated heat shock response
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
Degradation of GLI2 by the proteasome
Constitutive Signaling by AKT1 E17K in CancerR-HSA-2682334:EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
WikiPathways Transcriptional activation by NRF2
NLR Proteins
Regulation of Microtubule Cytoskeleton
L1CAM interactionsWP75:Toll-like receptor signaling pathway
Insulin Signaling
MAPK Cascade
MAPK Signaling Pathway
Nanoparticle-mediated activation of receptor signaling
Signal Transduction of S1P Receptor
Parkinsons Disease Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
NGF signalling via TRKA from the plasma membrane
Myogenesis
Integrin-mediated Cell Adhesion
DSCAM interactions
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
DNA Damage Response (only ATM dependent)
G13 Signaling Pathway
Wnt Signaling Pathway
Oxidative Stress
Wnt Signaling Pathway and Pluripotency
Apoptosis Modulation by HSP70
Structural Pathway of Interleukin 1 (IL-1)
Apoptosis
BDNF signaling pathway
Regulation of toll-like receptor signaling pathwayWP615:Senescence and Autophagy in Cancer
Endochondral Ossification
Focal Adhesion
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Signaling Pathways in Glioblastoma
TSH signaling pathway
MicroRNAs in cardiomyocyte hypertrophyWP707:DNA Damage Response
Meiotic Recombination
ATM Signaling Pathway
Integrated Pancreatic Cancer Pathway
Integrated Breast Cancer Pathway
Homologous recombination
Double-Strand Break Repair
miRNA Regulation of DNA Damage ResponseWP61:Notch Signaling Pathway
Interferon type I signaling pathways
IL-2 Signaling Pathway
Inflammatory Response Pathway
Signaling by SCF-KIT
DAP12 interactions
Host Interactions of HIV factors
PIP3 activates AKT signaling
T-Cell Receptor and Co-stimulatory Signaling
B Cell Receptor Signaling Pathway
TSLP Signaling Pathway
TCR signaling
Costimulation by the CD28 familyWP710:DNA Damage Response (only ATM dependent)
Senescence and Autophagy in Cancer
Notch Signaling Pathway
Glycogen Metabolism
IL-6 signaling pathway
Wnt Signaling Pathway Netpath
Copper homeostasis
Hair Follicle Development: Induction (Part 1 of 3)
Cardiac Hypertrophic Response
Degradation of beta-catenin by the destruction complex
Cardiac Progenitor Differentiation
Corticotropin-releasing hormone
IL17 signaling pathway
Neural Crest Differentiation
Alzheimers Disease
IL-7 Signaling Pathway
TWEAK Signaling Pathway
Leptin signaling pathway
Semaphorin interactions
Cell Cycle
MicroRNAs in cardiomyocyte hypertrophy
Androgen receptor signaling pathway
IL-5 Signaling PathwayWP2884:NRF2 pathway
References
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

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