Drug Information

Drug General Information
Drug ID
D0MT1N
Former ID
DNC014091
Drug Name
N-Ethyl-2-methylnorapomorphine hydrochloride
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530150]
Structure
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2D MOL

3D MOL
Formula
C19H22ClNO2
Canonical SMILES
CCN1CCC2=C3C1CC4=C(C3=CC(=C2)C)C(=C(C=C4)O)O.Cl
InChI
1S/C19H21NO2.ClH/c1-3-20-7-6-13-8-11(2)9-14-17(13)15(20)10-12-4-5-16(21)19(22)18(12)14;/h4-5,8-9,15,21-22H,3,6-7,10H2,1-2H3;1H/t15-;/m1./s1
InChIKey
VFIJPYCEACRORO-XFULWGLBSA-N
PubChem Compound ID
45267372
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Inhibitor [530150]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 530150Bioorg Med Chem. 2009 Jul 1;17(13):4756-62. Epub 2009 May 3.N-Substituted-2-alkyl- and 2-arylnorapomorphines: novel, highly active D2 agonists.
Ref 530150Bioorg Med Chem. 2009 Jul 1;17(13):4756-62. Epub 2009 May 3.N-Substituted-2-alkyl- and 2-arylnorapomorphines: novel, highly active D2 agonists.

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