Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0MW7B
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| Former ID |
DIB008971
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| Drug Name |
PF-4494700
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| Synonyms |
PF-04494700; TTP-488; TTP-488); Alzheimers therapy, TransTech/Pfizer; Diabetic nephropathy therapy, Transtech/Pfizer; Alzheimer'streatment, TransTech/Pfizer; Alzheimer's therapy (RAGE), Transtech/Pfizer
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| Drug Type |
Small molecular drug
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| Company |
Transtech pharma
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| Structure |
|
Download2D MOL |
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| Formula |
C32H38ClN3O2
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| InChI |
InChI=1S/C32H38ClN3O2/c1-4-7-9-32-34-31(25-10-16-28(17-11-25)37-23-8-22-35(5-2)6-3)24-36(32)27-14-20-30(21-15-27)38-29-18-12-26(33)13-19-29/h10-21,24H,4-9,22-23H2,1-3H3
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| InChIKey |
KJNNWYBAOPXVJY-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Advanced glycosylation end product-specific receptor | Target Info | Antagonist | [533109] | |
| Pathway Interaction Database | amb2 Integrin signaling | ||||
| References | |||||
| Ref 524669 | ClinicalTrials.gov (NCT02080364) Evaluation of the Efficacy and Safety of Azeliragon (TTP488) in Patients With Mild Alzheimer's Disease. U.S. National Institutes of Health. | ||||
| Ref 543068 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8317). | ||||
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