Drug Information

Drug General Information
Drug ID
D0N0JL
Former ID
DIB019757
Drug Name
diphosphoric acid
Synonyms
pyrophosphoric acid; phosphonooxyphosphonic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540142]
Structure
Download
2D MOL
Formula
H4O7P2
InChI
InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)
InChIKey
XPPKVPWEQAFLFU-UHFFFAOYSA-N
PubChem Compound ID
1023
PubChem Substance ID
3315, 571608, 596337, 819738, 820211, 820332, 820378, 820380, 820422, 820425, 820430, 820914, 821458, 822446, 823822, 824936, 827919, 828493, 829022, 830805, 830818, 831002, 831009, 832539, 833895, 834879, 835117, 836076, 837458, 837789, 838941, 854579, 854894, 855020, 855049, 855053, 855055, 855259, 4253134, 5315283, 7890028, 8017438, 8025140, 8026543, 8027659, 8028591, 8145399, 8150931, 10318169, 10320630
Target and Pathway
Target(s) Farnesyl pyrophosphatesynthetase Target Info Inhibitor [529362]
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
References
Ref 540142(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3151).
Ref 529362J Med Chem. 2008 Apr 10;51(7):2187-95. Epub 2008 Mar 8.Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

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