TTD | Drug: D0N0PU

Drug General Information
Drug ID	D0N0PU
Former ID	DCL000155
Drug Name	LTB 019
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Discontinued in Phase 2	[547374]
Company	Novartis
Structure		Download 2D MOL 3D MOL
Formula	C25H35N3O4
Canonical SMILES	CC(C)N(C(C)C)C(=O)C1=CC(=C(C=C1)OCCCCCOC2=CC=C(C=C2)C(=<br />N)N)O
InChI	1S/C25H35N3O4/c1-17(2)28(18(3)4)25(30)20-10-13-23(22(29)16-20)32-15-7-5-6-14-31-21-11-8-19(9-12-21)24(26)27/h8-13,16-18,29H,5-7,14-15H2,1-4H3,(H3,26,27)
InChIKey	LBVCAMSVLTWBRT-UHFFFAOYSA-N
PubChem Compound ID	56603680
PubChem Substance ID	134338834
Target and Pathway
Target(s)	Leukotriene B4 receptor 1	Target Info	Antagonist	[536562]
KEGG Pathway	Neuroactive ligand-receptor interaction
NetPath Pathway	IL4 Signaling Pathway
Reactome	Leukotriene receptors
Reactome	G alpha (q) signalling events
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 547374	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015581)
Ref 536562	Effect of the oral leukotriene B4 receptor antagonist LTB019 on inflammatory sputum markers in patients with chronic obstructive pulmonary disease. Pulm Pharmacol Ther. 2008;21(2):409-17.

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Drug Information