Drug Information

Drug General Information
Drug ID
D0N1HL
Former ID
DIB006724
Drug Name
Frakefamide
Synonyms
BCH-3963; LEF-553; LEF-576; SPD-759; LEF, AstraZeneca/BioChem Pharma
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Discontinued in Phase 2 [546587]
Company
Shire plc
Structure
Download
2D MOL

3D MOL
Formula
C30H34FN5O5
Canonical SMILES
C(=O)(N[C@H](C(=O)N)Cc1ccccc1)[C@@H](NC(=O)[C@H](NC(=O)<br />[C@H](Cc1ccc(cc1)O)N)C)Cc1ccc(F)cc1
PubChem Compound ID
5493563
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Agonist [527449]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 546587Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009073)
Ref 527449A novel molecule (frakefamide) with peripheral opioid properties: the effects on resting ventilation compared with morphine and placebo. Anesth Analg. 2005 Mar;100(3):713-7, table of contents.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.