Drug Information

Drug General Information
Drug ID
D0N1HW
Former ID
DNC000859
Drug Name
L-745,870
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Phase 2 [540265]
Structure
Download
2D MOL

3D MOL
Formula
C18H19ClN4
InChI
InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)
InChIKey
OGJGQVFWEPNYSB-UHFFFAOYSA-N
CAS Number
CAS 158985-00-3
PubChem Compound ID
5311200
PubChem Substance ID
5007730, 7979687, 11056334, 11111360, 11113847, 14850833, 24263007, 26752020, 39340909, 47365384, 47736667, 47880157, 48110628, 48254023, 50070526, 50071164, 50104687, 50924052, 53787753, 57304374, 57359386, 84970653, 85209133, 85788363, 90340721, 103165750, 103947633, 114155529, 124750001, 124880510, 124880511, 124880512, 128805148, 134341004, 135275785, 135710076, 136351193, 136897518, 137035783, 143160225, 162222310, 164779492, 170485727, 178100340, 179293898, 203086700, 223259268, 227308076, 252432821
Target and Pathway
Target(s) D(4) dopamine receptor Target Info Antagonist [535158], [536766]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 540265(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3303).
Ref 535158Comparative molecular field analysis of dopamine D4 receptor antagonists including 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo-[2,3-b]pyridine (L-745,870), and clozapine. J Med Chem. 2001 Apr 12;44(8):1151-7.
Ref 536766Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI. Psychopharmacology (Berl). 2009 Apr;203(2):265-77. Epub 2008 Jul 6.

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