Drug General Information
Drug ID
D0N2DN
Former ID
DNC008938
Drug Name
4-Phenylspiro[chromene-2,4'-piperidine]
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529689]
Structure
Download
2D MOL

3D MOL

Formula
C19H19NO
Canonical SMILES
C1CNCCC12C=C(C3=CC=CC=C3O2)C4=CC=CC=C4
InChI
1S/C19H19NO/c1-2-6-15(7-3-1)17-14-19(10-12-20-13-11-19)21-18-9-5-4-8-16(17)18/h1-9,14,20H,10-13H2
InChIKey
AWYPHZMWGAOGIC-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Inhibitor [529689]
Delta-type opioid receptor Target Info Inhibitor [529689]
Potassium voltage-gated channel subfamily H member 2 Target Info Inhibitor [529689]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-1296072:Voltage gated Potassium channels
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium Channels
References
Ref 529689J Med Chem. 2008 Oct 9;51(19):5893-6. Epub 2008 Sep 13.Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).
Ref 529689J Med Chem. 2008 Oct 9;51(19):5893-6. Epub 2008 Sep 13.Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).

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