Drug General Information
Drug ID
D0N4YP
Former ID
DNC013922
Drug Name
6-(3-aza-bicyclo[3.1.0]hexan-1-yl)quinoline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529523]
Structure
Download
2D MOL

3D MOL

Formula
C14H14N2
Canonical SMILES
C1C2C1(CNC2)C3=CC4=C(C=C3)N=CC=C4
InChI
1S/C14H14N2/c1-2-10-6-11(3-4-13(10)16-5-1)14-7-12(14)8-15-9-14/h1-6,12,15H,7-9H2
InChIKey
RJVNCNHNNCNEMX-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Inhibitor [529523]
Sodium-dependent dopamine transporter Target Info Inhibitor [529523]
KEGG Pathway Serotonergic synapsehsa04728:Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP727:Monoamine Transport
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 529523Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. Epub 2008 May 23.Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors.
Ref 529523Bioorg Med Chem Lett. 2008 Jul 1;18(13):3682-6. Epub 2008 May 23.Studies on the structure-activity relationship of bicifadine analogs as monoamine transporter inhibitors.

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