Drug Information

Drug General Information
Drug ID
D0N5LJ
Former ID
DNC000782
Drug Name
Igmesine
Drug Type
Small molecular drug
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Phase 2 [544891]
Structure
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2D MOL

3D MOL
Formula
C23H30ClN
Canonical SMILES
CCC(CC=CC1=CC=CC=C1)(C2=CC=CC=C2)N(C)CC3CC3.Cl
InChI
1S/C23H29N.ClH/c1-3-23(22-14-8-5-9-15-22,24(2)19-21-16-17-21)18-10-13-20-11-6-4-7-12-20;/h4-15,21H,3,16-19H2,1-2H3;1H/b13-10+;
InChIKey
SCHQQPAJNUHKSV-RSGUCCNWSA-N
CAS Number
CAS 140850-73-3
PubChem Compound ID
6438339
PubChem Substance ID
11968035, 12014707, 14925706, 43031347, 47206350, 49880389, 49880390, 50928221, 57367998, 114555869, 134223494, 134339199, 135078384, 160687145, 198965625, 232988894, 232992541, 241375887, 249617543, 252156450
Target and Pathway
Target(s) Sigma(1)-type opioid receptor Target Info Agonist [535460], [535948], [536208]
WikiPathways miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 544891Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001429)
Ref 535460Strain differences in sigma(1) receptor-mediated behaviours are related to neurosteroid levels. Eur J Neurosci. 2002 May;15(9):1523-34.
Ref 535948Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders. CNS Drugs. 2004;18(5):269-84.
Ref 536208Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas. J Pharmacol Exp Ther. 2006 Jun;317(3):1307-19. Epub 2006 Mar 21.

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