Drug Information

Drug General Information
Drug ID
D0N6OE
Former ID
DIB010939
Drug Name
Benafentrine dimaleate
Synonyms
AH-21-132; Benafentrine dimaleate < Rec INNM >; Cis-6-(4-Acetamidophenyl)-8,9-dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridine bis(hydrogenmaleate); Cis-4'-(1,2,3,4,4a,10b-Hexahydro-8,9-dimethoxy-2-methylbenzo[c][1,6]naphthyridin-6-yl)acetanilide bis(hydrogenmaleate); Cis-N-[4-(1,2,3,4,4a,10b-Hexahydro-8,9-dimethoxy-2-methylbenzo[c][1,6]naphthyridin-6-yl)phenyl]acetamide (Z)-2-butenedioate (1:2)
Drug Type
Small molecular drug
Indication Septic shock [ICD9: 785.52; ICD10:A41.9] Terminated [544550]
Structure
Download
2D MOL

3D MOL
Formula
C31H35N3O11
Canonical SMILES
CC(=O)NC1=CC=C(C=C1)C2=NC3CCN(CC3C4=CC(=C(C=C42)OC)OC)C<br />.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
InChI
1S/C23H27N3O3.2C4H4O4/c1-14(27)24-16-7-5-15(6-8-16)23-18-12-22(29-4)21(28-3)11-17(18)19-13-26(2)10-9-20(19)25-23;2*5-3(6)1-2-4(7)8/h5-8,11-12,19-20H,9-10,13H2,1-4H3,(H,24,27);2*1-2H,(H,5,6)(H,7,8)/b;2*2-1+/t19-,20-;;/m1../s1
InChIKey
BWJFLHODOYZAML-GODXOYSCSA-N
CAS Number
CAS 76166-55-7
PubChem Compound ID
6438805
PubChem Substance ID
43031775, 57368262, 75548416, 114557020, 134224223, 135082179
Target and Pathway
Target(s) Phosphodiesterase (PDE) 3 Target Info Modulator [533628]
References
Ref 544550Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000110)
Ref 533628Studies on anti-allergic action of AH 21-132, a novel isozyme-selective phosphodiesterase inhibitor in airways. Jpn J Pharmacol. 1995 Feb;67(2):149-56.

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