Drug General Information
Drug ID
D0N6YV
Former ID
DIB012782
Drug Name
Cenestin
Synonyms
Synthetic conjugated estrogens-A, Barr; Synthetic conjugated estrogens-A, Duramed
Drug Type
Small molecular drug
Indication Menopause symptoms [ICD10:N95.0] Approved [551871]
Company
Duramed Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL

Formula
C18H19NaO5S
Canonical SMILES
[Na+].O=S(=O)(Oc1cc2c([C@@H]3[C@H]([C@H]4[C@](CC3)(C(=O<br />)CC4)C)CC2)cc1)[O-].[Na+].O=S(=O)(Oc1cc2c([C@@H]3C(=CC2<br />)[C@H]2[C@](CC3)(C(=O)CC2)C)cc1)[O-]
CAS Number
CAS 12126-59-9
PubChem Compound ID
Target and Pathway
Target(s) Estrogen receptor Target Info Agonist [526290], [551871]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Proteoglycans in cancer
NetPath Pathway FSH Signaling Pathway
EGFR1 Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
Plasma membrane estrogen receptor signaling
LKB1 signaling events
Regulation of Telomerase
ATF-2 transcription factor network
AP-1 transcription factor network
FOXM1 transcription factor network
Validated nuclear estrogen receptor alpha network
Signaling mediated by p38-alpha and p38-beta
FOXA1 transcription factor network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Estrogen signaling pathway
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
Signaling by ERBB4
JAK/STAT
Integrated Pancreatic Cancer Pathway
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
Integrated Breast Cancer Pathway
Nuclear Receptors
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 526290Estrogen replacement therapy and cardioprotection: mechanisms and controversies. Braz J Med Biol Res. 2002 Mar;35(3):271-6.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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