Drug Information

Drug General Information
Drug ID
D0N7AD
Former ID
DAP001079
Drug Name
Azatadine
Synonyms
Azatadina; Azatadinum; Azatidine; Azatadine maleate; Azatadina [INN-Spanish]; Azatadine (INN); Azatadine [INN:BAN]; Azatadinum [INN-Latin]; 11-(1-Methyl-4-piperidinylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 6,11-Dihydro-11-(1-methyl-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine
Drug Type
Small molecular drug
Indication Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] Approved [538492], [542126]
Therapeutic Class
Antihistamines
Structure
Download
2D MOL

3D MOL
Formula
C20H22N2
InChI
InChI=1S/C20H22N2/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19/h2-7,12H,8-11,13-14H2,1H3
InChIKey
SEBMTIQKRHYNIT-UHFFFAOYSA-N
CAS Number
CAS 3964-81-6
PubChem Compound ID
19861
PubChem Substance ID
9976, 6866969, 8164714, 10521526, 14849144, 29287392, 46507958, 48415596, 49846682, 50064764, 50757318, 51091807, 57330489, 85209773, 87350405, 103246343, 104348992, 124894113, 125823507, 126670295, 127310116, 127310117, 129222881, 134221903, 134338336, 134985673, 137002504, 142408412, 144206535, 160964063, 164836026, 170464865, 172849907, 178103696, 179225221, 198960451, 210279291, 210281614, 223669450, 224555094, 226395842, 241076914, 250099142, 252411784, 252477770
SuperDrug ATC ID
R06AX09
SuperDrug CAS ID
cas=003964816
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [537651]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538492FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 017601.
Ref 542126(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7119).
Ref 537651Comparative effects of loratadine and azatadine in the treatment of seasonal allergic rhinitis. Asian Pac J Allergy Immunol. 1990 Dec;8(2):103-7.

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