Drug Information

Drug General Information
Drug ID
D0N7NK
Former ID
DIB019798
Drug Name
E6801
Synonyms
E 6801; E-6801
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540195]
Structure
Download
2D MOL
Formula
C17H18ClN5O2S2
InChI
InChI=1S/C17H18ClN5O2S2/c1-22(2)6-5-11-10-19-14-4-3-12(9-13(11)14)21-27(24,25)16-15(18)20-17-23(16)7-8-26-17/h3-4,7-10,19,21H,5-6H2,1-2H3
InChIKey
RZAXUKVIIWUIOM-UHFFFAOYSA-N
PubChem Compound ID
10202564
PubChem Substance ID
15200695, 22594447, 40317086, 74645772, 85301160, 103439799, 137939814, 140775863, 178100278, 198954261, 223370051, 227280212, 245632592, 248909648
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Agonist [527474]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540195(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3217).
Ref 527474J Med Chem. 2005 Mar 24;48(6):1781-95.Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.

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