Drug General Information
Drug ID	D0N7SG
Former ID	DIB010945
Drug Name	R-84760
Drug Type	Small molecular drug
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Discontinued in Phase 2	[546014]
Company	Sankyo Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C19H25Cl3N2OS
Canonical SMILES	C(=O)(N1[C@H](CN2CCCC2)CSCC1)[C@@H]1c2c(cc(c(c2)Cl)Cl)C<br />C1.Cl
CAS Number	CAS 157824-23-2
PubChem Compound ID	133035
Target and Pathway
Target(s)	Kappa-type opioid receptor	Target Info	Agonist	[534614]
KEGG Pathway	Neuroactive ligand-receptor interaction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Opioid prodynorphin pathway
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546014	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005881)
Ref 534614	Effects of R-84760, a selective kappa-opioid receptor agonist, on nociceptive reflex in isolated neonatal rat spinal cord. Eur J Pharmacol. 1998 Feb 19;343(2-3):171-7.

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